In July 1955, a branch of the National Mental Hospital (now National Center for Mental health) was established in Mariveles, Bataan to ease congestion in the main hospital. The Bureau of Quarantine donated the 3.8 hectares land and buildings of the Quarantine Station for National Mental Hospital Extension Service. The first batch of patients were transferred from the National Mental Hospital to Mariveles, Bataan, The NMH Extension Service facility was closed in 1960 for reasons that patient were out of reach by their families and the maintenance cost to run the facility was quite expensive.

   Three years later, the National Mental Hospital Extension Service was again reopened in December 1963, to help decongest the overcrowded National Mental Hospital. In June 1978 P.D. 1541 was promulgated paving the way for the regionalization of Mental Hospitals thus National Mental Hospital Extension Service was renamed Mariveles Mental Hospital and the technical and administrative supervision of the hospital was turned over to the Regional Health Office No.3 in San Fernando, Pampanga. Later in 1984, it was placed under the supervision of Central Luzon General Hospital (now the Jose B. Lingad Memorial Regional Hospital) also in San Fernando Pampanga; it was considered as psychiatric ward of this hospital thus renamed Mariveles Mental Ward.

   In 1988, the mental facility was integrated to the Provincial Health Office of Bataan by virtue of reintegration program of Department of Health to facilitate and ease the supervision of the hospital. It was devolved in 1993 by virtue of R.A. 7160 (local Government Code) to Provincial Government of Bataan. Due to financial difficulties the Provincial Government of Bataan requested that the Mariveles Mental Ward (MMW) be transferred to the Department of Health. Through Resolution No. 95-07 of the Oversight Committee on RA 7160, Mariveles Mental Ward was renationalized in 1996 and again placed under the supervision of Jose B. Lingad Memorial Regional Hospital. In 2001 when Bataan Provincial Hospital (now Bataan General Hospital) was renationalized under RA 8561, technical and administrative supervision was placed under the Chief of Hospital (COH) of Bataan General Hospital. On July 17, 2008, by virtue of license granted by the Department of Health, Center for Health Development 3, City of San Fernando, Pampanga, Mariveles Mental Ward was recognized as MARIVELES MENTAL HOSPITAL. The hospital Technical and Administrative supervision was directly placed under the Regional Director of Regional Health Office No. 3 in San Fernando, Pampanga until July 26, 2015. From July 27, 2015 to November 12, 2016 it was headed by Dr. Alberto C. De Leon, Chief of Hospital III by virtue of DPO No. 2015-2924 date June 29, 2015.

    Upon the retirement of Dr. Alberto De Leon, Dr. Leonita Gorgolon, Regional Director of DOH-RO3 headed MMH from November 13 to December 4, 2016. From December 5, 2016 to present, MMH is headed by Chief of Hospital II, Dr. Maria Lourdes L. Evangelista as per Department Personnel Order 2018-3234 dated July 17, 2018.